Formulation: A solid
Formal Name: cyclo[L-alloisoleucyl-N-methyl-L-valyl-L-leucyl-N,3-dimethyl-L-threonyl-(2R,3R)-2-hydroxy-3-methylpentanoyl-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl]
Purity: ≥95%
Formula Markup: C60H92N8O11
Formula Weight: 1101,4
Shelf life (days): 1460
CAS Number: 127785-64-2
Notes: Aureobasidin A is a cyclic depsipeptide that has been found in A. pullulans and has diverse biological activities.{67689,67690,67691} It inhibits inositol phosphorylceramide synthase, an enzyme involved in sphingolipid biosynthesis (Kis = 0.18 and 0.23 for the C. albicans and S. cerevisiae enzymes, respectively).{67689} Aureobasidin A also inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1; IC50 = 2.27 µM).{67690} It is active against various mammalian pathogenic fungi, including Candida and Cryptococcus (MICs = S. cerevisiae (MIC = 0.4 µg/ml).{67691,67690} Aureobasidin A (80 mg/kg, p.o.) increases survival in a mouse model of candidiasis induced by C. albicans.{67691}
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