AZ1 USP25/28 Inhibitor, CAS 2165322-94-9

Formulation: A solid

Formal Name: 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-ethanol

Purity: ≥98%

Formula Markup: C17H16BrF4NO2

Formula Weight: 422,2

Shelf life (days): 1460

CAS Number: 2165322-94-9

Notes: AZ1 USP25/28 Inhibitor is a dual inhibitor of ubiquitin-specific protease 25 (USP25) and USP28 (IC50s = 0.7 and 0.6 µM, respectively).{40571} It is selective for USP25 and USP28 over USP2a (IC50 = >100 µM), a panel of 22 other deubiquitinases at 10 µM, and a panel of eight caspases and cathepsins at 30 µM. AZ1 USP25/28 Inhibitor induces degradation of c-Myc in HCT116 cells in a concentration-dependent manner, an effect that can be reversed by the proteasome inhibitor MG132. It decreases the viability of several cancer cell lines (EC50s = 9.8-33.5 µM).

• SKU: CAY40335-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40335-5
• Package Unit: 5 mg
• Quantity Unit: STK