Formulation: A solid
Formal Name: (1α,1′R,4β)-4-methoxy-5′′-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-dispiro[cyclohexane-1,2′-[2H]indene-1′(3′H),2′′-[2H]imidazol]-4′′-amine
Purity: ≥98%
Formula Markup: C26H28N4O
Formula Weight: 412,5
Shelf life (days): 1460
CAS Number: 1383982-64-6
Notes: AZD 3293 is an inhibitor of β-secretase 1 (BACE1) and BACE2 (Kis = 0.4 and 0.8 nM, respectively).{69037} It is selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and human-ether-a-go-go (hERG; IC50s = 3,797, >25,000, and 4,700 nM, respectively). AZD 3293 inhibits the secretion of amyloid-β (1-40) (Aβ40) in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human amyloid precursor protein (APP; IC50 = 0.08 nM). In vivo, AZD 3293 (50, 100, and 200 µmol/kg) reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice.
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