AZD 4205, CAS 2091134-68-6

Formulation: A solid

Formal Name: (αR)-N-[3-[2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,4-dimethyl-1-piperazineacetamide

Purity: ≥98%

Formula Markup: C25H31N9O2

Formula Weight: 489,6

Shelf life (days): 1460

CAS Number: 2091134-68-6

Notes: AZD 4205 is a JAK1 inhibitor (IC50 = 0.07 µM).{68122} It is selective for JAK1 over JAK2 (IC50 = >15 µM). AZD 4205 inhibits the phosphorylation of STAT3 in H1975 non-small cell lung cancer (NSCLC) cells (IC50 = 0.13 µM). It enhances the antitumor activity of osimertinib (AZD 9291; Item No. 16237) in an H1975 mouse xenograft model when administered at a dose of 50 mg/kg.

• SKU: CAY36622-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36622-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe