AZD 4573, CAS 2057509-72-3

Formulation: A solid

Formal Name: (1S,3R)-3-(acetylamino)-N-[5-chloro-4-(5,6-dihydro-5,5-dimethyl-4H-pyrrolo[1,2-b]pyrazol-3-yl)-2-pyridinyl]-cyclohexanecarboxamide

Purity: ≥98%

Formula Markup: C22H28ClN5O2

Formula Weight: 429,9

Shelf life (days): 1460

CAS Number: 2057509-72-3

Notes: AZD 4573 is an inhibitor of cyclin-dependent kinase 9 (Cdk9; IC50 = 14 nM).{65821} It is selective for Cdk9 over Cdk1, Cdk7, Cdk4/6, and Cdk2 (IC50s = 370, 1,100, 1,100, and >10,000 nM, respectively). AZD 4573 (100 nM) induces apoptosis in MV4-11 acute myeloid leukemia (AML) cells. In vivo, AZD 4573 (15 mg/kg every other day), in combination with the Bcl-2 inhibitor venetoclax (ABT-199; Item No. 16233), reduces tumor volumes in SU-DHL-4 B cell lymphoma and OCI-AML-3 AML mouse xenograft models.

• SKU: CAY33306-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33306-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK