AZD 4604, CAS 2241039-81-4

Formulation: A solid

Formal Name: N-[3-[5-fluoro-2-[[2-fluoro-3-(methylsulfonyl)phenyl]amino]-4-pyrimidinyl]-1H-indol-7-yl]-αR-(methoxymethyl)-4-methyl-1-piperazineacetamide

Purity: ≥98%

Formula Markup: C28H31F2N7O4S

Formula Weight: 599,7

Shelf life (days): 1460

CAS Number: 2241039-81-4

Notes: AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM).{66652} It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2; IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD 4604 (1 mg/kg) reduces lung STAT3 and STAT5 phosphorylation in a rat model of ovalbumin-induced asthma.{66653} It also inhibits lung eosinophilia and reduces the late asthmatic response in the same model.

• SKU: CAY39890-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39890-10
• Package Unit: 10 mg
• Quantity Unit: STK