Formulation: A solid
Formal Name: N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Purity: ≥98%
Formula Markup: C23H27ClN4O3
Formula Weight: 442,9
Shelf life (days): 1460
CAS Number: 476159-98-5
Notes: AZM475271 is an inhibitor of c-Src kinase (IC50 = 0.01 µM).{66157} It inhibits phosphorylation of c-Src kinase, Lck, c-Yes, and VEGFR2 (IC50s = 0.01, 0.03, 0.08, and 0.7 µM, respectively).{66158} AZM475271 inhibits proliferation of NIH3T3 fibroblasts, as well as PC3 and DU145 prostate and A549 lung cancer cells (IC50s = 0.5, 32, 16, and 17 µM, respectively). It reduces tumor cell proliferation and microvessel density and increases apoptosis in an L3.6pl pancreatic cancer mouse xenograft model when administered at a dose of 50 mg/kg per day. AZM475271 inhibits tumor growth and metastasis in the same mouse xenograft model when administered in combination with gemcitabine (Item Nos. 11690 / 9003096).
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