Bax Channel Blocker, CAS 335165-68-9

Formulation: A solid

Formal Name: 3,6-dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol

Purity: ≥98%

Formula Markup: C19H21Br2N3O

Formula Weight: 467,2

Shelf life (days): 1460

CAS Number: 335165-68-9

Notes: Bax channel blocker is an inhibitor of Bax.{69537} It binds to Bax in a cell-free assay (Kd = 15 µM) and inhibits Bax-mediated membrane permeabilization induced by the membrane-targeted death ligand tBID in a liposomal release assay (IC50 = 3.3 µM). Bax channel blocker inhibits apoptosis induced by TNF-α- and the protein synthesis inhibitor cycloheximide (Item No. 14126) in mouse embryonic fibroblasts (MEFs; IC50 = 1.8 µM). It also inhibits cell death induced by the Bax activator BTSA1 (Item No. 37305) in OCI-AML-3 cells.

• SKU: CAY37538-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37538-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK