BAY-1816032, CAS 1891087-61-8

Formulation: A solid

Formal Name: 2-[3,5-difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]-ethanol

Purity: ≥98%

Formula Markup: C27H24F2N6O4

Formula Weight: 534,5

Shelf life (days): 1460

CAS Number: 1891087-61-8

Notes: BAY-1816032 is an inhibitor of the mitotic checkpoint serine/threonine protein kinase BUB1 (IC50 = 6.1 nM).{62656} It is selective for BUB1 over FLT3 (IC50 = 4.2 µM) and 15 other kinases (IC50s = >10 µM for all). BAY-1816032 inhibits proliferation of a variety of cancer cells (median IC50 = 1.4 µM) and acts synergistically with the mitotic inhibitor paclitaxel (Item No. 10461) to increase the rate of chromosomal segregation defects during mitosis in HeLa cells. It reduces tumor growth in a SUM149 mouse xenograft model when administered at a dose of 25 mg/kg and has an additive effect on reducing tumor growth when used in combination with paclitaxel in the same model.

• SKU: CAY35095-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35095-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe