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Biological Activity: BAY-60-7550 inhibits PDE2 with an IC50 of 2.0 nM in bovine, and 4.7 nMin humans.
CAS Number: 439083-90-6
Description: BAY-60-7550 is a potent inhibitor of PDE2. It is more selective for PDE2 than PDE1 by 50-fold. Similarly, it is 100-fold more selective for PDE4B, PDE5B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.
Format: A crystalline solid
Purity: ≥95% by HPLC
Solubility: Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol,DMSO and DMF is ~10 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Boess, F.G., et al., Neuropharmacology. 2004; 47: 1081-1092.
2. Masood, A., et al., J. Pharmacol. Exp. Ther. 2008; 326(2): 369-379.
3. Rutten, K., et al., Neuropsychopharmacology. 2009; 34: 1914-1925.
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