Formulation: A solid
Formal Name: 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-2-propanol
Purity: ≥98%
Formula Markup: C24H24F3NO2
Formula Weight: 415,5
Shelf life (days): 1460
CAS Number: 2222094-18-8
Notes: BC-1618 is an inhibitor of F-box only protein 48 (FBXO48), an E3 ubiquitin ligase.{67018} It is selective for FBXO48 over FBXO30 at 3 µM. BC-1618 (0.5-10 µM) increases the levels of phosphorylated AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC), an AMPK downstream substrate, in HEK293T cells expressing human FBXO48. It induces mitochondrial fission in BEAS-2B cells and autophagy in HEK293A cells expressing GFP-tagged LC3. BC-1618 also inhibits LPS-induced activation of NF-κB in THP-1 cells in a reporter assay and cytokine release in isolated human peripheral blood mononuclear cells (PBMCs). It increases insulin sensitivity in a mouse model of high-fat diet-induced obesity when administered at a dose of 20 mg/kg.
English
Deutsch
