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Background: Bendamustine inhibits mitotic checkpoints and induces mitotic catastrophe by inhibiting several mitosis-related genes such as Polo-like kinase 1, Aurora kinase A, and Cyclin B1. In myeloma cell lines, bendamustine induced apoptosis by cleavage of caspase 3, and resulted in G2 cell cycle arrest. In chronic lymphocytic and mantle cell lymphoma cell lines, bendamustine HCl has been shown to activate both the mitochondrial cell death pathway and caspase-dependent apoptosis.
Biological Activity: Bendamustine exhibited anti-proliferation effects on dexamethasone-sensitive (MM1.S) and -resistant (MM1.R) multiple myeloma cells in a dose-dependent manner, with IC50s of 119.8 µM (MM1.S) and 138 µM (MM1.R), respectively. The apoptosis by activation of caspase-3 and caspase-8 was induced in both MM1.S and MM1.R cell lines.
CAS Number: 3543-75-7
Description: Bendamustine HCl is an alkylating agent associated with DNA damage (IC50 = 50 µM). It is a cytostatic agent that displays activity in non-Hodgkin's lymphomas.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
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