BH400

Formulation: A solid

Formal Name: 5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid

Purity: ≥95%

Formula Markup: C20H16FNO3

Formula Weight: 337,4

Shelf life (days): 730

Notes: BH400 is an agonist of peroxisome proliferator-activated receptor α (PPARα) and an inhibitor of stimulator of interferon genes (STING; IC50 = 8.1 µM).{72553} It induces transactivation of PPARα in a reporter assay using THP-1 cells (EC50 = 1.2 µM). BH400 (10 µM) inhibits decreases in viability induced by 4-hydroxy nonenal (4-HNE; Item No. 32100) or hydrogen peroxide (H2O2) in 661W retinal ganglion cells. It prevents LPS-induced increases in phosphorylated TANK-binding kinase 1 (TBK1) and IL-6 levels and LPS-induced decreases in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) levels in HMC3 microglial cells when used at a concentration of 10 µM.

• SKU: CAY41892-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41892-1
• Package Unit: 1 mg
• Quantity Unit: STK