BI-4394, CAS 1222173-37-6

Formulation: A solid

Formal Name: 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylic acid, 2-ethyl ester

Purity: ≥95%

Formula Markup: C24H22N4O5

Formula Weight: 446,5

Shelf life (days): 1460

CAS Number: 1222173-37-6

Notes: BI-4394 is an inhibitor of matrix metalloproteinase-13 (MMP-13; IC50 = 0.001 µM for the recombinant human enzyme).{67078} It is selective for MMP-13 over MMP-1-3, 7-10, -12, and -14 with IC50 values ranging from 8.3 to greater than 22 µM for the recombinant human enzymes. BI-4394 inhibits the degradation of isolated bovine nasal cartilage explants cultured with human MMP-13 (IC50 = 0.031 µM). It decreases disease severity in a mouse model of anti-type II collagen antibody and LPS-induced arthritis when administered at a dose of 100 mg/kg.{67079}

• SKU: CAY36855-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36855-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe