BMS-299897, CAS 290315-45-6

Formulation: A solid

Formal Name: 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid

Purity: ≥98%

Formula Markup: C24H21ClF3NO4S

Formula Weight: 511,9

Shelf life (days): 730

CAS Number: 290315-45-6

Notes: BMS-299897 is an inhibitor of γ-secretase.{35888,57908,57909} It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively).{57908} BMS-299897 (0.1-1 nmol/animal) reduces increases in amyloid-β (1-42) (Aβ42) levels induced by Aβ (25-35) in the mouse hippocampus.{57909} It also prevents deficits induced by Aβ (25-35) in the novel object recognition test when tested with a one-hour, but not a 24-hour, intertrial interval in the same model.

• SKU: CAY35777-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35777-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe