BMS 582949, CAS 623152-17-0

Formulation: A crystalline solid

Formal Name: 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Purity: ≥98%

Formula Markup: C22H26N6O2

Formula Weight: 406,5

Shelf life (days): 1460

CAS Number: 623152-17-0

Notes: BMS 582949 is an orally bioavailable p38α MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-α production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice, it decreases LPS-induced TNF-α production up to 89% compared to vehicle. BMS 582949 reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg).

• SKU: CAY22892-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22892-10
• Package Unit: 10 mg
• Quantity Unit: STK