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Amino Acid Sequence: Boc-Asp(OMe)-CH?F
Background: Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα) with IC50 value of 39 µM. Boc-D-FMK has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-κB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibits TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, Boc-D-FMK has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates.
CAS Number: 187389-53-3,634911-80-1
Description: A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies--see note for using this product in vitro.
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: pan-caspase
Biosafety Level: Not applicable (BSL-1)
References: 1. Cowburn AS,et al. Blood. 2005 Apr 1;105(7):2970-2.
2. Wu X, et al. Am J Physiol Renal Physiol. 2009 Aug;297(2):F316-26.
3. Sheen-Chen SM, et al. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9.
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