BPH-1358, CAS 5352-53-4

Formulation: A solid

Formal Name: N4,N4′-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-[1,1′-biphenyl]-4,4′-dicarboxamide

Purity: ≥95%

Formula Markup: C32H28N6O2 • 2HCl

Formula Weight: 601,5

Shelf life (days): 1460

CAS Number: 5352-53-4

Notes: BPH-1358 is an inhibitor of undecaprenyl diphosphate synthase (UPPS; IC50 = 0.11 µM for the E. coli and S. aureus enzymes), an enzyme involved in bacterial cell wall biosynthesis.{67190} It is also an inhibitor of farnesyl diphosphate synthase (FPPS; IC50 = 1.8 µM for the human enzyme), an enzyme in the mevalonate pathway of cholesterol and isoprenoid biosynthesis.{67191} BPH-1358 is active against E. coli and S. aureus (EC50s = 0.3 and 0.29 nM, respectively) and increases survival in a mouse model of S. aureus infection when administered at a dose of 10 mg/kg.{67190}

• SKU: CAY37402-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37402-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe