BRD6989, CAS 642008-81-9

Formulation: A solid

Formal Name: 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

Purity: ≥98%

Formula Markup: C16H16N4

Formula Weight: 264,3

Shelf life (days): 1460

CAS Number: 642008-81-9

Notes: BRD6989 is an inhibitor of the Cdk8/cyclin C complex.{69055} It selectively binds to the Cdk8/cyclin C complex (IC50 = ~200 nM) over the Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p35, Cdk7/cyclin H, and Cdk9/cyclin T complexes at 1,000 nM. BRD6989 increases the production of IL-10 in primary mouse bone marrow-derived dendritic cells (BMDCs) stimulated with zymosan A (Item No. 21175) with an EC50 value of approximately 1 µM and reduces zymosan A-induced increases in IL-6 levels in the same cells.

• SKU: CAY35358-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35358-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe