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CAS Number: 20350-15-6
Description: Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus and induces apoptosis in human tumor cells via caspase activation. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.
Format: White to off-white solid.
Purity: ≥99%
Solubility: Soluble in DMSO at 100 mg/ml; soluble in 100% ethanol at 25 mg/ml with slight warming, methanol, acetone or ethyl acetate (1 mg/ml). Very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Misumi, Y., et al. J. Biol. Chem. 261: 11398-11403 (1986).
2. Guo, H., et al. Exp. Cell Res. 245: 57-68 (1998).
3. Linardic, C. M., et al. Cell Growth Differ. 7: 765-774 (1996).
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