Formulation: A solid
Formal Name: 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide
Purity: ≥98%
Formula Markup: C18H17ClFNO5
Formula Weight: 381,8
Shelf life (days): 1095
CAS Number: 2922824-09-5
Notes: C18 is a covalent inhibitor of glutathione peroxidase 4 (GPX4; IC50 = 120 nM).{65816} It inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 breast cancer cells (IC50s = 10, 75, and 12 nM, respectively). C18 (10 and 20 µM) increases lipid peroxidation and oxidized malondialdehyde (MDA) levels in MDA-MB-231 cells, an effect that can be prevented by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729). It decreases mitochondrial volume and induces degradation of mitochondrial crests and outer membranes in MDA-MB-231 cells when used at a concentration of 20 µM. In vivo, C18 (5, 10, or 20 mg/kg) reduces tumor volume and weight, without affecting body weight, in an MDA-MB-231 mouse xenograft model.
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