Formulation: A crystalline solid
Formal Name: 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98%
Formula Markup: C25H19ClF4N2O2
Formula Weight: 490,9
Shelf life (days): 730
CAS Number: 2259624-71-8
Notes: C53 is a STING agonist.{66165} It activates human wild-type STING (EC50 = 185 nM), as well as STING containing the polymorphisms R232, H232, or HAQ in HEK293 cells in an interferon-stimulated gene 54 (ISG54) luciferase reporter assay when used at a concentration of 10 µM. C53 (10 µM) induces the expression of IFN-α, IFN-β, TNF-α, chemokine (C-X-C motif) ligand 10 (CXCL10), IL-12p40, and IL-6 in isolated human monocyte-derived dendritic cells (hMO-DCs). It also increases the expression of the dendritic cell markers CD83 and CD86 in hMO-DCs when used at a concentration of 10 µM.
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