Formulation: A crystalline solid
Formal Name: 3-(2-methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
Purity: ≥98%
Formula Markup: C28H25NO6
Formula Weight: 471,5
Shelf life (days): 1460
CAS Number: 1233706-88-1
Notes: Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.{18732} It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} The phase I metabolite of this compound, CAY10641 (Item No. 10662), is also available.
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