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Biological Activity: CBHA exhibits an IC50 of 0.01 µM and 0.07 µM in vitro for HDAC1 and HDAC3 respectively.
CAS Number: 174664-65-4
Description: M-Carboxycinnamic Acid bishydroxamide, or CBHA, is a potent histone deacetylase (HDAC) inhibitor. CBHA has been found to induce apoptosis in nine different neuroblastoma cell lines in culture. It can also completely suppress neuroblastoma tumor growth in SCID mice at 200 mg/kg.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO and DMF at 20 mg/ml. First, dissolve in DMSO then dilute with the aqueous buffer of choice.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Richon, V.M., et al., Proc. Natl. Acad. Sci. 1998; 95: 3003 - 3007.
2. Glick, R.D., et al., Cancer Res. 1999; 59: 4392 - 4399.
3. Coffey, D.C., et al., Cancer Res. 2001; 61: 3591 - 3594.
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