Formulation: A crystalline solid
Formal Name: 6,6′-[(3,3′-dimethoxy[1,1′-biphenyl]-4,4′-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid, tetrasodium salt
Purity: ≥90%
Formula Markup: C34H24N6O16S4 • 4Na
Formula Weight: 992,8
Shelf life (days): 1460
CAS Number: 2610-05-1
Notes: CSB6B is a dye and derivative of glutamate with diverse biological activities.{59218,59219,59220,59221,59222} It is a competitive inhibitor of vesicular glutamate transporters (vGLUTs), inhibiting glutamate uptake by rat brain synaptic vesicles (Ki = 0.19 µM) but not by synaptosomes when used at a concentration of 0.1 mM.{59218} CSB6B is also an inhibitor of calcium/calmodulin-dependent protein kinase phosphatase (CaMKP) and its nuclear isoform CaMKP-N (IC50s = 4.1 and 1 µM, respectively).{59219} It is selective for CaMKP and CaMKP-N over protein phosphatase 2C (PP2C) and calcineurin, which it inhibits by less than 10 and 20%, respectively, at 10 µM. CSB6B inhibits sodium/taurocholate cotransporting polypeptide (NTCP; IC50 = 7.1 µM) and reduces hepatitis B virus (HBV) and hepatitis delta virus (HDV) infection in HepaRG cells when used at a concentration of 17 µM.{59220} Intracerebroventricular administration of CSB6B (0.5 µg) inhibits inflammatory pain in mice, reducing writhing induced by acetic acid and nociceptive behavior during the second phase of the formalin test without affecting locomotor activity.{59221} It also reduces thermal hyperalgesia in the complete Freund’s adjuvant test but not thermal pain in the hot plate test. CSB6B has also been used as a counterstain to reduce background autofluorescence in immunohistochemical preparations.{59222}
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