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CAS Number: 112522-64-2
Description: CI-994 is a histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation. CI-994 inhibited HDAC-1 and HDAC-2 but not GCN5. CI-994 is also a novel antitumor agent, exhibiting activity against pancreatic, colon and mammary tumors. CI-994 inhibited the growth of two non-small cell lung cancer cell lines, A-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma), with an IC50 of 80 µM.
Format: White to off-white powder
Purity: ≥99%
Solubility: Soluble in DMSO at 66 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kraker, A.J., et al. Mol. Cancer Ther. 2: 401-408 (2003).
2. LoRusso, P.M., et al. Invest. New Drugs 14: 349-356 (1996).
3. Loprevite, M., et al. Oncol. Res. 15: 39-48 (2005).
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