Formulation: A solid
Formal Name: (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Purity: ≥98%
Formula Markup: C20H27N3O5
Formula Weight: 389,5
Shelf life (days): 1460
CAS Number: 90139-06-3
Notes: Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.7 nM for the rat enzyme) and an active metabolite of cilazapril (Item No. 29777).{65330,62524} It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 µM.{68432} Intra-arterial administration of cilazaprilat (3 µg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.{68433}
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