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Background: Cilostazol (OPC-13013, Pletal) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. Cilostazol is used in the treatment of peripheral arterial disease and claudication (leg cramps). Cilostazol inhibits platelet aggregation and is a direct arterial vasodilator.
CAS Number: 73963-72-1
Description: Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 µM and inhibitor of adenosine uptake.
Format: white to off-white crystals
Solubility: Soluble in DMSO (18 mg/ml).
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PDE3
Biosafety Level: Not applicable (BSL-1)
References: 1. Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
2. Liu Y, et al. Cardiovasc Drug Rev, 2001, 19(4), 369-386.
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