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Background: Cisplatin induces cytotoxicity by interaction with DNA to form intrastrand crosslinks which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. Stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-?B content and translocation in macrophages.
CAS Number: 15663-27-1
Description: Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.
Solubility: Soluble in DMSO
Storage Stability: Store at room temperature. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Biosafety Level: Not applicable (BSL-1)
References: 1. Seki et al (2000). Cancer Chemother.Pharmacol. 45 199.
2. Duan et al (2004). Clin.Cancer Res. 10 234.
2. Nomura et al (2004). Urol.Oncology 22 453.
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