Formulation: A solid
Formal Name: (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-(methyl-d3)-4-propylpyrrolidine-2-carboxamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18H30D3ClN2O5S • HCl
Formula Weight: 464,5
Shelf life (days): 1460
CAS Number: 1356933-72-6
Notes: Clindamycin-d3 is intended for use as an internal standard for the quantification of clindamycin (Item Nos. 15006 / 35581) by GC- or LC-MS. Clindamycin is a lincosamide antibiotic.{60231,57596} It is active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively).{60231} Clindamycin is also active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively).{57596} It inhibits bacterial protein synthesis by interacting with the 50S ribosome.{60231} Clindamycin increases survival in a mouse model of a secondary S. pneumoniae infection when administered at a dose of 15 mg/kg twice daily for seven days.{57597} Formulations containing clindamycin have been used in the treatment of bacterial infections.
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