Formulation: A solid
Formal Name: (2S-trans)-methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside, monohydrochloride, monohydrate
Purity: ≥98%
Formula Markup: C18H33ClN2O5S • HCl [H2O]
Formula Weight: 479,5
Shelf life (days): 1460
CAS Number: 58207-19-5
Notes: Clindamycin is a lincosamide antibiotic.{60231,57596} It is active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively).{60231} Clindamycin is also active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively).{57596} It inhibits bacterial protein synthesis by interacting with the 50S ribosome.{60231} Clindamycin increases survival in a mouse model of a secondary S. pneumoniae infection when administered at a dose of 15 mg/kg twice daily for seven days.{57597} Formulations containing clindamycin have been used in the treatment of bacterial infections.
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