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Biological Activity: Costunolide is an inhibitor of human telomerase activity (IC50 = 65 µM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines.Selectively blocks endothelial cell proliferation induced by VEGF and inhibits the VEGFR KDR/Flk-1 signaling pathway. Inhibits expression of iNOS and IL-1β and disrupts NF-?B activation. Exposure of T24 cells to costunolide was associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP.
CAS Number: 553-21-9
Description: Costunolide is a sesquiterpene lactone with anti-oxidant properties that is found in lettuce and other plants. It is widely used in many herbal medicines. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Park et al (1996). J.Nat.Prod. 59 1128.
2. Jeong et al (2002). Cancer Lett. 187 129.
3. Choi et al (2005). Cancer Lett. 227 153.
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