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Biological Activity: CP-80633 inhibits PDE4 isozymes (human lung IC50 = 1.27 µM) in the absence of effects on PDE1, PDE2, PDE3 and PDE5 isozymes (IC50 > 100 µM).
CAS Number: 135637-46-6
Description: CP 80633 is a selective inhibitor of PDE4, which does not display significant isozyme selectivity. It also inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T-cells. It has been shown to exhibit anti-inflammatory and bronchodilatory activity in vivo.
Format: A crystalline solid
Purity: ≥95% by HPLC
Solubility: Soluble in 100 mM DMSO or 100 mM Ethanol.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Turner, CR., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1349-55.
2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.
3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6.
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