Formulation: A solid
Formal Name: 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]-benzoic acid
Purity: ≥95%
Formula Markup: C13H9ClN2O6S
Formula Weight: 356,7
Shelf life (days): 1460
CAS Number: 68003-38-3
Notes: CTPI-2 is an inhibitor of the mitochondrial citrate transporter, also known as SLC25A1.{64767} It decreases the oxygen consumption rate (OCR) in tumor spheres isolated from patients with non-small cell lung cancer (NSCLC) and inhibits the invasion of lung cancer stem cells in vitro. CTPI-2 (50 µM) acts synergistically with cisplatin (Item No. 13119) to reduce the viability of cisplatin-resistant patient-derived NSCLC cells. It reverses increases in body weight, steatosis, and fasting blood glucose levels in a mouse model of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg.{64768}
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