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Background: CUDC-907 has a long half-life in murine tumors. CUDC-907 induces apoptosis and inhibits cancer cell proliferation in xenograft tumors.
Biological Activity: CUDC-907 inhibits HDAC1, 2, 3, 6, 8, 10, and 11 with IC50 of 1.7 nM, 5 nM, 1.8 nM, 27 nM, 191 nM, 2.8 nM, and 5.4 nM, respectively. CUDC-907 inhibits PI3Kα (IC50 of 19 nM) and other PI3K isoforms such as PI3Kβ, PI3Kγ, PI3Kδ, PI3KαH1047R and PI3KαE545K with IC50 of 54 nM, 311 nM, 39 nM, 73 nM and 62 nM, respectively. CUDC-907 suppresses other types of HDAC enzymatic activity with lower potency.
CAS Number: 1339928-25-4
Description: CUDC-907 is a dual PI3K and HDAC inhibitor
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: HDAC, PI3K
Biosafety Level: Not applicable (BSL-1)
References: Qian C, et al. Clin Cancer Res. 2012 Aug 1;18(15):4104-13.
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