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Biological Activity: Acetylation of histones H3 and H4 by p300/CBP was strongly inhibited by curcumin with an IC50 25 µM.
CAS Number: 458-37-7
Description: Curcumin, also known as diferuloylmethane, natural yellow 3, or C.I. 75300, is the principal curcuminoid of the popular Indian spice turmeric, which is a small molecule, selective HAT inhibitor. It has shown to promote degradation of p300 and inhibits the acetyltransferases activity of purified p300 using either histone H3 or p53 as a substrate.
Format: Yellow powder.
Purity: ≥94% by HPLC
Solubility: Soluble in acetone, ethanol and DMSO.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Marcu, MG. et al., Med. Chem. 2006 Mar; 2(2): 169-174.
2. Kundu, TK. et al., Journal of Biological Chemistry (2004); 279(49):51163-51171.
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