Formulation: A powder
Formal Name: (5S,6S)-5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one, monosodium salt
Purity: ≥75%
Formula Markup: C21H32O7P • Na
Formula Weight: 450,4
Shelf life (days): 1460
CAS Number: 457070-06-3
Notes: Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice.{31268,31270} It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml).{31272} Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.{31269,31271}
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