Formulation: A crystalline solid
Formal Name: N-[4-[(3′-chloro-6-methoxy[1,1′-biphenyl]-3-yl)methyl]phenyl]-urea
Purity: ≥98%
Formula Markup: C21H19ClN2O2
Formula Weight: 366,8
Shelf life (days): 1460
CAS Number: 1155877-97-6
Notes: D159687 is a negative allosteric modulator of phosphodiesterase 4D (PDE4D; IC50 = 28 nM for the human enzyme).{67418} It is selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM). D159687 decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253 nM) and dextran gel-induced increases in leukotriene E4 production in isolated human whole blood (IC50 = 44 nM). It impairs novel object recognition in mice when administered at a dose of 3 mg/kg but does not increase anesthesia duration, a proxy measure of emesis induction, in mice at 3 or 10 mg/kg.{67420}
English
Deutsch
