Danicamtiv, CAS 1970972-74-7

Formulation: A solid

Formal Name: 4-[(1R)-1-[[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-1-piperidinecarboxamide

Purity: ≥98%

Formula Markup: C16H20F3N5O4S

Formula Weight: 435,4

Shelf life (days): 1460

CAS Number: 1970972-74-7

Notes: Danicamtiv is a cardiac-specific myosin activator.{69039,69040} It activates human cardiac S1 myosin when used at a concentration of 3 µM but does not activate skeletal or smooth muscle myosin.{69039} It increases sarcomere activity of isolated porcine left ventricular and atrial myofibrils with 50% active concentration values (AC50s) of 6 and 3.6 µM, respectively. Danicamtiv (3 µM) increases calcium sensitivity of isolated porcine skinned left ventricular and atrial fibers. Danicamtiv (2-3 mg/kg) also prolongs systolic ejection time and improves left ventricular ejection fraction and stroke volume in a dog model of heart failure.

• SKU: CAY36875-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36875-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe