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Applications: Useful for the study of the ubiquitin-dependent and endoplasmic reticulum-associated degradation pathway (p97 ATPase)
CAS Number: 177355-84-9
Description: DBeQ is cell permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 µM. DBeQ blocks both ubiquitin dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.
Format: Yellow powder
Purity: >98% by TLC.
Solubility: Soluble in DMSO (25 mg/ml)
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.
Warnings: Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: 1. Chou TF, et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. USA. 2011. Mar 22; 108:4834-9.
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