Formulation: A crystalline solid
Formal Name: 5-(2,3-dichlorophenyl)-2-[[[2-(4-morpholinyl)ethyl]amino]methylene]-1,3-cyclohexanedione
Purity: ≥95%
Formula Markup: C19H22Cl2N2O3
Formula Weight: 397,3
Shelf life (days): 730
CAS Number: 2868312-73-4
Notes: DC-LC3in-D5 is an inhibitor of LC3 (IC50 = 200 nM).{55946} It selectively binds to LC3-I and LC3-II over GABA type A receptor-associated protein (GABARAP), scavenger receptor class B member 2 (SCARB2), and paraoxonase 2 (PON2) in an activity-based protein profiling (ABPP) assay using HeLa cells. DC-LC3in-D5 (25 µM) inhibits LC3-II lipidation, autophagosome formation, and the protein-protein interaction between LC3-II and ATG7 in HeLa cells.