Defensamide, CAS 1104874-94-3

Formulation: A solid

Formal Name: N-(1-oxohexyl)-L-tyrosine, methyl ester

Purity: ≥98%

Formula Markup: C16H23NO4

Formula Weight: 293,4

Shelf life (days): 1460

CAS Number: 1104874-94-3

Notes: Defensamide is an activator of sphingosine kinase 1 (SPHK1).{69538} It increases sphingosine-1-phosphate (S1P) levels in primary human keratinocytes but does not affect S1P lyase activity in the same cells when used at a concentration of 100 µM. Defensamide (100 µM) increases protein levels of cathelicidin antimicrobial peptide (CAMP), also known as LL-37 (Item No. 24461), in primary human keratinocytes. It inhibits the invasion of S. aureus into murine skin ex vivo. Defensamide has also been used as an intermediate in the synthesis of the fungal metabolites sinuxylamide A as well as compounds with anticancer and antibacterial activities.{69539,69540}

• SKU: CAY37318-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37318-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK