Formulation: A solid
Formal Name: (3R,3aS,9R,9aS,9bS)-3-[(dimethylamino)methyl]-3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-azuleno[4,5-b]furan-2(3H)-one
Purity: ≥95%
Formula Markup: C17H27NO3
Formula Weight: 293,4
Shelf life (days): 1460
CAS Number: 1403357-81-2
Notes: Dimethylamino-micheliolide (DMAMCL) is a prodrug form of the sesquiterpene lactone micheliolide (Item No. 25402).{69724} It inhibits migration and invasion of, and vascular formation by, U-118 MG glioma cells when used at a concentration of 10 µM. DMAMCL enhances cell death induced by the DNA-cross-linking agent cisplatin (Item No. 13119) in U-118 MG cells. In vivo, DMAMCL (200 mg/kg) reduces tumor volume and slows the tumor growth rate in a U-118 MG mouse xenograft model when administered in combination with cisplatin. It also prevents proteinuria and renal failure in a db/db mouse model of diabetic nephropathy.{69725}
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