Formulation: A solid
Formal Name: rel-N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride
Purity: ≥98%
Formula Markup: C23H38N2O3 • HCl
Formula Weight: 427
Shelf life (days): 1460
CAS Number: 80943-40-4
Notes: DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.{11392,62049} It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 µM.{62049} Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 µM.{11341} It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 µM but is cytotoxic at concentrations higher than 50 µM.{62050} [Matreya, LLC. Catalog No. 1755]
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