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Background: Donepezil HCl is a piperidine-class AChE inhibitor containing an N-benzylpiperdine and an indanone moiety, which confers it a longer and more selective action against AchE as compared to BuChE (IC50: 7.4 µM). Donepezil HCl has been shown to improve cognitive function of mild to severe moderate AD patients and exhibits excellent tolerability without hepatotoxicity.
CAS Number: 120011-70-3
Solubility: Insoluble in EtOH; insoluble in DMSO; ≥10.4 mg/mL in H2O. For obtaining a highersolubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: acetylcholinesterase (AChE)
Biosafety Level: Not applicable (BSL-1)
References: Birks, J., Harvey, R.J . Cochrane Database Syst Rev. 2006 Jan 25;(1):CD001190.
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