Doramapimod (GMP), CAS 285983-48-4

Product Description: Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC50s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity[1].

Formula: C31H37N5O3

References: [1]Cicenas J, et al., JNK, p38, ERK, and SGK1 Inhibitors in Cancer. Cancers (Basel). 2017 Dec 21;10(1):1.

CAS Number: 285983-48-4

Molecular Weight: 527.66

Research Area: Cancer

Target: p38 MAPK

• SKU: MEXHY-10320G-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10320G-0
• Package Unit: Get quote
• Quantity Unit: STK