Formulation: A crystalline solid
Formal Name: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide, 7,7-dioxide, monohydrochloride
Purity: ≥98%
Formula Markup: C10H16N2O4S3 • HCl
Formula Weight: 360,9
Shelf life (days): 1460
CAS Number: 130693-82-2
Notes: Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}
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