Formulation: A solid
Formal Name: (OC-6-21)-[4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-sulfur
Purity: ≥98%
Formula Markup: C14H12F7N5S
Formula Weight: 415,3
Shelf life (days): 1460
CAS Number: 1282041-94-4
Notes: DSM 265 is an antimalarial agent and inhibitor of P. falciparum and P. vivax dihydroorotate dehydrogenase (DHODH; IC50s = 8.9 and 27 nM, respectively).{62661} It is selective for P. falciparum and P. vivax DHODH over human, rabbit, pig, and monkey DHODH (IC50s = >41 µg/ml) but does inhibit P. cynomolgi, dog, mouse, and rat DHODH (IC50s = 0.005, 11, 1.1, and 0.82 µg/ml, respectively).{62662} DSM 265 inhibits the growth of the P. falciparum strain 3D7 with an EC50 value of 4.3 nM.{62661} It also reduces blood parasitemia in mice (ED90 = 1.5 mg/kg twice per day).{62662}
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