Formulation: A solid
Formal Name: 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-5-thiazolecarboxylic acid, ethyl ester
Purity: ≥98%
Formula Markup: C22H23F2N3O2S
Formula Weight: 431,5
Shelf life (days): 1460
CAS Number: 2222768-84-3
Notes: Dynarrestin is an inhibitor of dynein 1 and -2.{65221} It inhibits dynein 1-dependent microtubule gliding (IC50 = 5 µM) and dynein 2-dependent intraflagellar transport in mIMCD-3 inner medullary collecting duct cells when used at concentrations of 0.125 and 1.25 µM. Dynarrestin decreases the number of cells in metaphase, anaphase, or telophase in asynchronous COS-7 cells (IC50 = 6.25 µM). It inhibits the proliferation of primary Ptch+/- murine medulloblastoma cells (IC50 = 0.068 µM) and the expression of GLI1 in KYSE-180 esophageal squamous cell carcinoma cells stimulated with the smoothened (Smo) agonist purmorphamine (Item No. 10009634; IC50 = 0.21 µM).
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