Products from BPS Bioscience require a minimum order value above 400€
Background: Elesclomol (also known as STA-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ROS) and the induction of unmanageable levels of oxidative stress. Elesclomol exhibits autitumor activity against a broad spectrum of types of cancer cell in human tumor xengograft models due to its excessive ROS production and elevated levels of oxidative stress leading to the death of cancer cells. Elesclomol is currently being studies as a novel cancer therapeutic, in which it has demonstrated ability to prolong progression-free survival in study subjects. Elesclomol induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells. Elesclomol requires a redox active metal ion to function; the Cu(II) complex is 34 times more potent than the Ni(II) complex and 1040-fold more potent than the Pt(II) complex.
CAS Number: 488832-69-5
Description: Elesclomol induces oxidative stress and triggers mitochondrial-induced apoptosis in cancer cells.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: HSP90
Biosafety Level: Not applicable (BSL-1)
References: 1. Blackman, RK, et al. PLoS ONE 2012; 7(1): e29798
2. Kirshner, JR., et al. Mol Cancer Ther 2008; 7:2319-2327
English
Deutsch
